Giants at Cubs Prediction: Odds, expert picks, starting pitchers, betting trends and stats for May 5

Its Monday, May 5 and the Giants (22-13) are in Chicago to take on the Cubs (21-14). Landen Roupp is slated to take the mound for San Francisco against Matthew Boyd for Chicago.

The Giants are coming off a 9-3 win over the Colorado Rockies. They won the series 3-1.

Logan Webb picked up the win. He only gave up one run on six hits in 7.0 innings. Willy Adames was great. He had two runs, three RBIs, on three hits.

The Cubs lost last night against the Milwaukee Brewers, but won the season series. The Cubs are 21-14 and are 1st in the National League Central.

Lets dive into the matchup and find a sweat or two.

We’ve got all the info and analysis you need to know ahead of the game, including the latest info on the how to catch tipoff, odds, recent team performance, player stats, and of course, our predictions, picks & best bets for the game from our modeling tools and staff of experts.

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Game details & how to watch Giants at Cubs

• Date: Monday, May 5, 2025
• Time: 7:40PM EST
• Site: Wrigley Field
• City: Chicago, IL
• Network/Streaming: Marquee Sports Network, NBCS BA

Never miss a second of the action and stay up-to-date with all the latest team stats and player news. Check out our day-by-day MLB schedule page, along with detailed matchup pages that update live in-game with every out.

Odds for the Giants at the Cubs

The latest odds as of Monday:

• Moneyline: Giants (+126), Cubs (-151)
• Spread:  Cubs -1.5
• Total: 7.0 runs

Probable starting pitchers for Giants at Cubs

• Pitching matchup for May 5, 2025: Landen Roupp vs. Matthew Boyd
  
  • Giants: Landen Roupp, (2-2, 5.10 ERA)
    Last outing (San Diego Padres, 4/30): 4.1 Innings Pitched, 4 Earned Runs Allowed, 7 Hits Allowed, 3 Walks, and 4 Strikeouts
  • Cubs: Matthew Boyd, (2-2, 2.70 ERA)
    Last outing (Pittsburgh Pirates, 4/30): 5.0 Innings Pitched, 2 Earned Runs Allowed, 6 Hits Allowed, 3 Walks, and 6 Strikeouts

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Top betting trends & insights to know ahead of Giants at Cubs

• The Giants have won 4 of their last 5 matchups against NL Central teams
• The Over is 20-14-1 in Giants' games this season
• The Giants have covered the Run Line in 3 straight games

If you’re looking for more key trends and stats around the spread, moneyline and total for every single game on the schedule today, check out our MLB Top Trends tool on NBC Sports!

Expert picks & predictions for tonight’s game between the Giants and the Cubs

Rotoworld Best Bet

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Our model calculates projections around each moneyline, spread and over/under bet for every game on the MLB calendar based on data points like past performance, player matchups, ballpark information and weather forecasts.

Once the model is finished running, we put its projection next to the latest betting lines for the game to arrive at a relative confidence level for each wager.

Here are the best bets our model is projecting for Monday's game between the Giants and the Cubs:

• Moneyline: NBC Sports Bet is staying away from a play on the Moneyline.
• Spread: NBC Sports Bet is leaning towards a play ATS on the San Francisco Giants at +1.5.
• Total: NBC Sports Bet is recommending a play on the over on the Game Total of 7.0.

Want even more MLB best bets and predictions from our expert staff & tools? Check out the Expert MLB Predictions page from NBC

Follow our experts on socials to keep up with all the latest content from the staff:

• Jay Croucher (@croucherJD)
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• Vaughn Dalzell (@VmoneySports)
• Brad Thomas (@MrBradThomas)