Mariners at White Sox prediction: Odds, expert picks, starting pitchers, betting trends, and stats for May 19

Its Monday, May 19 and the Mariners (26-19) are in Chicago to take on the White Sox (14-33).

Luis Castillo is slated to take the mound for Seattle against Davis Martin for Chicago.

The Mariners swept three games over the weekend in San Diego. They allowed a mere three runs to the Padres outscoring them 15-3 in the three-game set. Yesterday Bryan Woo allowed one run over seven innings in a 6-1 win.

The Sox were swept over the weekend in a series against the Cubs. Jonathan Cannon gave up three runs in five innings in a 6-2 loss yesterday.

Lets dive into the matchup and find a sweat or two.

We’ve got all the info and analysis you need to know ahead of the game, including the latest info on the how to catch tipoff, odds, recent team performance, player stats, and of course, our predictions, picks & best bets for the game from our modeling tools and staff of experts.

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Game details & how to watch Mariners at White Sox

• Date: Monday, May 19, 2025
• Time: 7:40PM EST
• Site: Rate Field
• City: Chicago, IL
• Network/Streaming: RSNW, CHSN

Never miss a second of the action and stay up-to-date with all the latest team stats and player news. Check out our day-by-day MLB schedule page, along with detailed matchup pages that update live in-game with every out.

Odds for the Mariners at the White Sox

The latest odds as of Monday:

• Moneyline: Mariners (-206), White Sox (+170)
• Spread:  Mariners -1.5
• Total: 8.0 runs

Probable starting pitchers for Mariners at White Sox

• Pitching matchup for May 19, 2025: Luis Castillo vs. Davis Martin
  
  • Mariners: Luis Castillo (3-3, 3.65 ERA)
    Last outing: 5/14 vs. Yankees - 6IP, 1ER, 6H, 2BB, 6Ks
  • White Sox: Davis Martin (2-4, 3.65 ERA)
    Last outing: 5/14 at Cincinnati - 6.2IP, 1ER, 7H, 0BB, 5Ks

Rotoworld still has you covered with all the latest MLB player news for all 30 teams. Check out the feed page right here on NBC Sports for headlines, injuries and transactions where you can filter by league, team, positions and news type!

Top betting trends & insights to know ahead of Mariners at White Sox

• The Mariners have won 4 of their last 5 games, while the White Sox have lost 4 in a row
• Each of the last 3 games between the Mariners and the White Sox have gone over the Total
• It has been 4 games since the White Sox last covered the Run Line
• Randy Arozarena went 4-13 (.308) in the three games against San Diego
• Luis Robert Jr. is 2-15 (.133) over his last 4 games

If you’re looking for more key trends and stats around the spread, moneyline and total for every single game on the schedule today, check out our MLB Top Trends tool on NBC Sports!

Expert picks & predictions for tonight’s game between the Mariners and the White Sox

Rotoworld Best Bet

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Our model calculates projections around each moneyline, spread and over/under bet for every game on the MLB calendar based on data points like past performance, player matchups, ballpark information and weather forecasts.

Once the model is finished running, we put its projection next to the latest betting lines for the game to arrive at a relative confidence level for each wager.

Here are the best bets our model is projecting for Monday's game between the Mariners and the White Sox:

• Moneyline: NBC Sports Bet is recommending a play on the Seattle Mariners on the Moneyline.
• Spread: NBC Sports Bet is leaning towards a play ATS on the Seattle Mariners at -1.5.
• Total: NBC Sports Bet is recommending a play on the under on the Game Total of 8.0.

Want even more MLB best bets and predictions from our expert staff & tools? Check out the Expert MLB Predictions page from NBC

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• Jay Croucher (@croucherJD)
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• Brad Thomas (@MrBradThomas)