Marlins at Padres prediction: Odds, expert picks, starting pitchers, betting trends, and stats for May 27

Its Tuesday, May 27 and the Marlins (21-31) are in San Diego to take on the Padres (30-22). Max Meyer is slated to take the mound for Miami against Stephen Kolek for San Diego.

The Padres took Game 1 of the series, 4-3 yesterday behind a Manny Machado homer in the bottom eighth. San Diego has followed up a six-game losing streak with three victories in the past four games. Miami's two-game winning streak was snapped yesterday as the Marlins are 2-4 in the last six.

Lets dive into the matchup and find a sweat or two. We’ve got all the info and analysis you need to know ahead of the game, including the latest info on the how to catch tipoff, odds, recent team performance, player stats, and of course, our predictions, picks & best bets for the game from our modeling tools and staff of experts.

Follow Rotoworld Player News for the latest fantasy and betting player news and analysis all season long.

Game details & how to watch Marlins at Padres

• Date: Tuesday, May 27, 2025
• Time: 9:40PM EST
• Site: Petco Park
• City: San Diego, CA
• Network/Streaming: FDSNFL, SDPA

Never miss a second of the action and stay up-to-date with all the latest team stats and player news. Check out our day-by-day MLB schedule page, along with detailed matchup pages that update live in-game with every out.

Odds for the Marlins at the Padres

The latest odds as of Tuesday:

• Moneyline: Marlins (+152), Padres (-183)
• Spread:  Padres -1.5
• Total: 8.0 runs

Probable starting pitchers for Marlins at Padres

• Pitching matchup for May 27, 2025: Max Meyer vs. Stephen Kolek
  
  • Marlins: Max Meyer, (3-4, 4.15 ERA)
    Last outing: 6.0 Innings Pitched, 1 Earned Run Allowed, 5 Hits Allowed, 1 Walk, and 4 Strikeouts
  • Padres: Stephen Kolek, (2-1, 2.84 ERA)
    Last outing: 6.0 Innings Pitched, 3 Earned Runs Allowed, 7 Hits Allowed, 3 Walks, and 6 Strikeouts

Rotoworld still has you covered with all the latest MLB player news for all 30 teams. Check out the feed page right here on NBC Sports for headlines, injuries and transactions where you can filter by league, team, positions and news type!

Expert picks & predictions for tonight’s game between the Marlins and the Padres

Rotoworld Best Bet

Please bet responsibly. If you or someone you know has a gambling problem, call the National Gambling Helpline at 1-800-522-4700.

Our model calculates projections around each moneyline, spread and over/under bet for every game on the MLB calendar based on data points like past performance, player matchups, ballpark information and weather forecasts.

Once the model is finished running, we put its projection next to the latest betting lines for the game to arrive at a relative confidence level for each wager.

Here are the best bets our model is projecting for Tuesday’s game between the Marlins and the Padres:

• Moneyline: NBC Sports Bet is recommending a play on the San Diego Padres on the Moneyline.
• Spread: NBC Sports Bet is leaning towards a play ATS on the Miami Marlins at +1.5.
• Total: NBC Sports Bet is staying away from a play on the Game Total of 8.0.

Want even more MLB best bets and predictions from our expert staff & tools? Check out the Expert MLB Predictions page from NBC.

Top betting trends & insights to know ahead of Marlins at Padres

• The Padres have won 4 of their last 5 matchups against NL East teams
• The Padres' last 5 home games have stayed under the Total
• The Marlins have covered in 4 of their last 5 games for a profit of 1.73 units

If you’re looking for more key trends and stats around the spread, moneyline and total for every single game on the schedule today, check out our MLB Top Trends tool on NBC Sports!

Follow our experts on socials to keep up with all the latest content from the staff:

• Jay Croucher (@croucherJD)
• Drew Dinsick (@whale_capper)
• Vaughn Dalzell (@VmoneySports)
• Brad Thomas (@MrBradThomas)