Mets at Red Sox prediction: Odds, expert picks, starting pitchers, betting trends, and stats for May 21

It's Wednesday, May 21 and the Mets (29-20) are in Boston to take on the Red Sox (25-25). Tylor Megill is slated to take the mound for New York against Garrett Crochet for Boston.

Boston is looking for the sweep after 2-0 and 3-1 victories over the last two days against the Mets. The Red Sox have won three of the past four games, while the Mets have dropped three straight and five of the past six.

Let's dive into the matchup and find a sweat or two. We’ve got all the info and analysis you need to know ahead of the game, including the latest info on how to catch tipoff, odds, recent team performance, player stats, and of course, our predictions, picks & best bets for the game from our modeling tools and staff of experts.

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Game details & how to watch Mets at Red Sox

• Date: Wednesday, May 21, 2025
• Time: 6:45 PM EST
• Site: Fenway Park
• City: Boston, MA
• Network/Streaming: SNY, NESN, MLBN

Never miss a second of the action and stay up-to-date with all the latest team stats and player news. Check out our day-by-day MLB schedule page, along with detailed matchup pages that update live in-game with every out.

Odds for the Mets at the Red Sox

The latest odds as of Wednesday:

• Moneyline: Mets (+126), Red Sox (-151)
• Spread:  Red Sox -1.5
• Total: 8.0 runs

Probable starting pitchers for Mets at Red Sox

• Pitching matchup for May 21, 2025: Tylor Megill vs. Garrett Crochet
  
  • Mets: Tylor Megill, (3-4, 3.74 ERA)
    Last outing: 2.2 Innings Pitched, 4 Earned Runs Allowed, 4 Hits Allowed, 5 Walks, and 4 Strikeouts
  • Red Sox: Garrett Crochet, (4-3, 2.00 ERA)
    Last outing: 7.0 Innings Pitched, 2 Earned Runs Allowed, 7 Hits Allowed, 0 Walks, and 8 Strikeouts

Rotoworld still has you covered with all the latest MLB player news for all 30 teams. Check out the feed page right here on NBC Sports for headlines, injuries and transactions where you can filter by league, team, positions and news type!

Expert picks & predictions for tonight’s game between the Mets and the Red Sox

Rotoworld Best Bet

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Our model calculates projections around each moneyline, spread and over/under bet for every game on the MLB calendar based on data points like past performance, player matchups, ballpark information and weather forecasts.

Once the model is finished running, we put its projection next to the latest betting lines for the game to arrive at a relative confidence level for each wager.

Here are the best bets our model is projecting for Wednesday’s game between the Mets and the Red Sox:

• Moneyline: NBC Sports Bet is staying away from a play on the Moneyline.
• Spread: NBC Sports Bet is leaning towards a play ATS on the New York Mets at +1.5.
• Total: NBC Sports Bet is recommending a play on the over on the Game Total of 8.0.

Want even more MLB best bets and predictions from our expert staff & tools? Check out the Expert MLB Predictions page from NBC.

Top betting trends & insights to know ahead of Mets at Red Sox

• The Mets have won 13 of 19 games following a defeat
• 6 of the Mets' last 7 games (86%) have stayed under the Total
• The Mets have failed to cover the Run Line in 6 of their last 7 road games against the Red Sox

If you’re looking for more key trends and stats around the spread, moneyline and total for every single game on the schedule today, check out our MLB Top Trends tool on NBC Sports!

Follow our experts on socials to keep up with all the latest content from the staff:

• Jay Croucher (@croucherJD)
• Drew Dinsick (@whale_capper)
• Vaughn Dalzell (@VmoneySports)
• Brad Thomas (@MrBradThomas)