Tigers at White Sox Prediction: Odds, expert picks, starting pitchers, betting trends and stats for June 5

Its Thursday, June 5 and the Tigers (41-22) are in Chicago to take on the White Sox (19-43).

Casey Mize is slated to take the mound for Detroit against Sean Burke for Chicago.

The Tigers have won two of the first three games of this series following last night's 5-4 win. Riley Greene went 3-5 and drove in two runs as Detroit won their 41st game of the season. Chase Meidroth went 3-4 in the loss for the Sox.

Lets dive into this afternoon's matchup and find a sweat or two.

We’ve got all the info and analysis you need to know ahead of the game, including the latest info on the how to catch tipoff, odds, recent team performance, player stats, and of course, our predictions, picks & best bets for the game from our modeling tools and staff of experts.

Follow Rotoworld Player News for the latest fantasy and betting player news and analysis all season long.

Game details & how to watch Tigers at White Sox

• Date: Thursday, June 5, 2025
• Time: 2:10PM EST
• Site: Rate Field
• City: Chicago, IL
• Network/Streaming: FDSNDT, CHSN

Never miss a second of the action and stay up-to-date with all the latest team stats and player news. Check out our day-by-day MLB schedule page, along with detailed matchup pages that update live in-game with every out.

Odds for the Tigers at the White Sox

The latest odds as of Thursday:

• Moneyline: Tigers (-218), White Sox (+180)
• Spread:  Tigers -1.5
• Total: 8.0 runs

Probable starting pitchers for Tigers at White Sox

• Pitching matchup for June 5, 2025: Casey Mize vs. Sean Burke
  
  • Tigers: Casey Mize (6-1, 2.82 ERA)
    Last outing: 5/30 at Kansas City - 3.1IP, 3ER, 8H, 2BB, 4Ks
  • White Sox: Sean Burke (3-6, 4.20 ERA)
    Last outing: 5/30 at Baltimore - 6IP, 2ER, 5H, 1BB, 6Ks

Rotoworld still has you covered with all the latest MLB player news for all 30 teams. Check out the feed page right here on NBC Sports for headlines, injuries and transactions where you can filter by league, team, positions and news type!

Top betting trends & insights to know ahead of Tigers at White Sox

• The Tigers have won 4 of their last 5 series
• Each of the White Sox's last 3 home games against the Tigers have gone over the Total
• The White Sox are showing a profit of 2.22 units on the Run Line in their last 5 games at Rate Field
• Riley Greene is enjoying a modest 4-game hitting streak with 8 hits in 16ABs (.500) in June

If you’re looking for more key trends and stats around the spread, moneyline and total for every single game on the schedule today, check out our MLB Top Trends tool on NBC Sports!

Expert picks & predictions for tonight’s game between the Tigers and the White Sox

Rotoworld Best Bet

Please bet responsibly. If you or someone you know has a gambling problem, call the National Gambling Helpline at 1-800-522-4700.

Our model calculates projections around each moneyline, spread and over/under bet for every game on the MLB calendar based on data points like past performance, player matchups, ballpark information and weather forecasts.

Once the model is finished running, we put its projection next to the latest betting lines for the game to arrive at a relative confidence level for each wager.

Here are the best bets our model is projecting for Thursday's game between the Tigers and the White Sox:

• Moneyline: NBC Sports Bet is recommending a play on the Detroit Tigers on the Moneyline.
• Spread: NBC Sports Bet is leaning towards a play ATS on the at -1.5.
• Total: NBC Sports Bet is recommending a play on the over on the Game Total of 8.0.

Want even more MLB best bets and predictions from our expert staff & tools? Check out the Expert MLB Predictions page from NBC

Follow our experts on socials to keep up with all the latest content from the staff:

• Jay Croucher (@croucherJD)
• Drew Dinsick (@whale_capper)
• Vaughn Dalzell (@VmoneySports)
• Brad Thomas (@MrBradThomas)