Cubs at Nationals Prediction: Odds, expert picks, starting pitchers, betting trends, and stats for June 4

It's Wednesday, June 4 and the Cubs (38-22) are in Washington to take on the Nationals (28-32). Matthew Boyd is slated to take the mound for Chicago against MacKenzie Gore for Washington.

Chicago took Game 1 of the series, 8-3, to extend their winning streak to three-straight and seven of the past eight.

The Cubs have won the last three starts with Boyd on the mound and won four of the past five. The Nats are 5-7 in Gore's 12 starts this season.

Let's dive into the matchup and find a sweat or two. We’ve got all the info and analysis you need to know ahead of the game, including the latest info on how to catch tipoff, odds, recent team performance, player stats, and of course, our predictions, picks & best bets for the game from our modeling tools and staff of experts.

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Game details & how to watch Cubs at Nationals

• Date: Wednesday, June 4, 2025
• Time: 6:45PM EST
• Site: Nationals Park
• City: Washington, DC
• Network/Streaming: MARQ, MASN

Never miss a second of the action and stay up-to-date with all the latest team stats and player news. Check out our day-by-day MLB schedule page, along with detailed matchup pages that update live in-game with every out.

Odds for the Cubs at the Nationals

The latest odds as of Wednesday:

• Moneyline: Cubs (-136), Nationals (+115)
• Spread:  Cubs -1.5
• Total: 8.0 runs

Probable starting pitchers for Cubs at Nationals

• Pitching matchup for June 4, 2025: Matthew Boyd vs. MacKenzie Gore
  
  • Cubs: Matthew Boyd, (5-2, 3.08 ERA)
    Last outing: 6.0 Innings Pitched, 0 Earned Runs Allowed, 4 Hits Allowed, 0 Walks, and 8 Strikeouts
  • Nationals: MacKenzie Gore, (2-5, 3.16 ERA)
    Last outing: 6.0 Innings Pitched, 0 Earned Runs Allowed, 4 Hits Allowed, 0 Walks, and 8 Strikeouts

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Expert picks & predictions for tonight’s game between the Cubs and the Nationals

Rotoworld Best Bet

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Our model calculates projections around each moneyline, spread and over/under bet for every game on the MLB calendar based on data points like past performance, player matchups, ballpark information and weather forecasts.

Once the model is finished running, we put its projection next to the latest betting lines for the game to arrive at a relative confidence level for each wager.

Here are the best bets our model is projecting for Wednesday’s game between the Cubs and the Nationals:

• Moneyline: NBC Sports Bet is recommending a play on the Chicago Cubs on the Moneyline.
• Spread: NBC Sports Bet is leaning towards a play ATS on the Washington Nationals at +1.5.
• Total: NBC Sports Bet is recommending a play on the over on the Game Total of 8.0.

Want even more MLB best bets and predictions from our expert staff & tools? Check out the Expert MLB Predictions page from NBC.

Top betting trends & insights to know ahead of Cubs at Nationals

• The Cubs have won 5 of their last 6 games on the road
• The Over is 34-21-5 in Cubs' games this season
• The Cubs have covered the Run Line in 3 straight games

If you’re looking for more key trends and stats around the spread, moneyline and total for every single game on the schedule today, check out our MLB Top Trends tool on NBC Sports!

Follow our experts on socials to keep up with all the latest content from the staff:

• Jay Croucher (@croucherJD)
• Drew Dinsick (@whale_capper)
• Vaughn Dalzell (@VmoneySports)
• Brad Thomas (@MrBradThomas)