Mets at Red Sox Prediction: Odds, expert picks, starting pitchers, betting trends and stats for May 20

Its Tuesday, May 20 and the Mets (29-19) are in Boston to take on the Red Sox (24-25).

Clay Holmes is slated to take the mound for New York against Walker Buehler for Boston.

The Sox took Game 1 of the series winning last night, 3-1. Boston scored three runs in the first two innings off Mets' ace Kodai Senga and it proved to be enough to pull the Red Sox within one game of .500. Jarren Duran paced the attack with a couple of hits and an RBI.

Lets dive into the matchup and find a sweat or two.

We’ve got all the info and analysis you need to know ahead of the game, including the latest info on the how to catch tipoff, odds, recent team performance, player stats, and of course, our predictions, picks & best bets for the game from our modeling tools and staff of experts.

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Game details & how to watch Mets at Red Sox

• Date: Tuesday, May 20, 2025
• Time: 6:45PM EST
• Site: Fenway Park
• City: Boston, MA
• Network/Streaming: SNY, NESN, TBS

Never miss a second of the action and stay up-to-date with all the latest team stats and player news. Check out our day-by-day MLB schedule page, along with detailed matchup pages that update live in-game with every out.

Odds for the Mets at the Red Sox

The latest odds as of Tuesday:

• Moneyline: Mets (-125), Red Sox (+105)
• Spread:  Mets -1.5
• Total: 9.0 runs

Probable starting pitchers for Mets at Red Sox

• Pitching matchup for May 20, 2025: Clay Holmes vs. Walker Buehler
  
  • Mets: Clay Holmes (5-2, 3.14 ERA)
    Last outing: 5/14 vs. Pittsburgh - 6IP, 4ER, 7H, 1BB, 4Ks
  • Red Sox: Walker Buehler (4-1, 4.28 ERA)
    Last outing: 4/26 at Cleveland - 6IP, 3ER, 7H, 1BB, 3Ks

Rotoworld still has you covered with all the latest MLB player news for all 30 teams. Check out the feed page right here on NBC Sports for headlines, injuries and transactions where you can filter by league, team, positions and news type!

Top betting trends & insights to know ahead of Mets at Red Sox

• The Mets have won 13 of 18 games following a defeat
• The Under is 4-1 in the Mets' last 5 games
• The Mets have failed to cover the Run Line in 5 of their last 6 games at Fenway
• This is Walker Buehler's first start in the month of May
• Pete Alonso is 4-22 (.182) over his last 6 games

If you’re looking for more key trends and stats around the spread, moneyline and total for every single game on the schedule today, check out our MLB Top Trends tool on NBC Sports!

Expert picks & predictions for tonight’s game between the Mets and the Red Sox

Rotoworld Best Bet

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Our model calculates projections around each moneyline, spread and over/under bet for every game on the MLB calendar based on data points like past performance, player matchups, ballpark information and weather forecasts.

Once the model is finished running, we put its projection next to the latest betting lines for the game to arrive at a relative confidence level for each wager.

Here are the best bets our model is projecting for Tuesday's game between the Mets and the Red Sox:

• Moneyline: NBC Sports Bet is recommending a play on the New York Mets on the Moneyline.
• Spread: NBC Sports Bet is staying away from a play against the spread.
• Total: NBC Sports Bet is recommending a play on the over on the Game Total of 9.0.

Want even more MLB best bets and predictions from our expert staff & tools? Check out the Expert MLB Predictions page from NBC

Follow our experts on socials to keep up with all the latest content from the staff:

• Jay Croucher (@croucherJD)
• Drew Dinsick (@whale_capper)
• Vaughn Dalzell (@VmoneySports)
• Brad Thomas (@MrBradThomas)