Reds at Guardians Prediction: Odds, expert picks, starting pitchers, betting trends and stats for June 11

It's Wednesday, June 11 and the Reds (35-33) are in Cleveland to take on the Guardians (34-32). Nick Lodolo is slated to take the mound for Cincinnati against Logan Allen for Cleveland.

The Reds are winners of five straight and six of the past seven, including yesterday's 1-0 win over the Guardians. Cincinnati has the chance to go for the sweep today and their second straight.

Cleveland lost five of the past six games and are in jeopardy of dropping to .500 with two more losses.

Let's dive into the matchup and find a sweat or two. We’ve got all the info and analysis you need to know ahead of the game, including the latest info on how to catch tipoff, odds, recent team performance, player stats, and of course, our predictions, picks & best bets for the game from our modeling tools and staff of experts.

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Game details & how to watch Reds at Guardians

• Date: Wednesday, June 11, 2025
• Time: 1:10PM EST
• Site: Progressive Field
• City: Cleveland, OH
• Network/Streaming: FDSNOH, CLEG

Never miss a second of the action and stay up-to-date with all the latest team stats and player news. Check out our day-by-day MLB schedule page, along with detailed matchup pages that update live in-game with every out.

Odds for the Reds at the Guardians

The latest odds as of Wednesday:

• Moneyline: Reds (-105), Guardians (-115)
• Spread:  Guardians -1.5
• Total: 8.0 runs

Probable starting pitchers for Reds at Guardians

• Pitching matchup for June 11, 2025: Nick Lodolo vs. Logan Allen
  
  • Reds: Nick Lodolo, (4-4, 3.21 ERA)
    Last outing: 6.0 Innings Pitched, 3 Earned Runs Allowed, 5 Hits Allowed, 0 Walks, and 4 Strikeouts
  • Guardians: Logan Allen, (3-4, 4.42 ERA)
    Last outing: 6.0 Innings Pitched, 4 Earned Runs Allowed, 7 Hits Allowed, 2 Walks, and 2 Strikeouts

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Expert picks & predictions for tonight’s game between the Reds and the Guardians

Rotoworld Best Bet

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Our model calculates projections around each moneyline, spread and over/under bet for every game on the MLB calendar based on data points like past performance, player matchups, ballpark information and weather forecasts.

Once the model is finished running, we put its projection next to the latest betting lines for the game to arrive at a relative confidence level for each wager.

Here are the best bets our model is projecting for Wednesday’s game between the Reds and the Guardians:

• Moneyline: NBC Sports Bet is recommending a play on the Cleveland Guardians on the Moneyline.
• Spread: NBC Sports Bet is leaning towards a play ATS on the Cincinnati Reds at +1.5.
• Total: NBC Sports Bet is recommending a play on the over on the Game Total of 8.0.

Want even more MLB best bets and predictions from our expert staff & tools? Check out the Expert MLB Predictions page from NBC.

Top betting trends & insights to know ahead of Reds at Guardians

• The Reds are 6-7 when Nick Lodolo pitches this season
• The Guardians are 6-6 when Logan Allen pitches this season
• The Guardians have won 18 of their 33 home games this season
• The Under is 7-3 in the Guardians' last 10 games
• The Guardians have failed to cover the Run Line in 5 straight matchups against the Reds

If you’re looking for more key trends and stats around the spread, moneyline and total for every single game on the schedule today, check out our MLB Top Trends tool on NBC Sports!

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• Jay Croucher (@croucherJD)
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• Vaughn Dalzell (@VmoneySports)
• Brad Thomas (@MrBradThomas)